In Vitro Fertilization or commonly called IVF which means fertilization outside the body is UpToDate innovation on assist reproductive technology which shows successful pregnancy rate about 30%-40%, the highest success rate if compare to other treatment. However, the success rate can be varied by many factors such as age, embryo quality etc.

The treatment starts from using injection every day for 8-10 days to stimulate the ovary to produce multiple eggs. The eggs are then collected and fertilized with the prepared sperm under proper environmental controlled conditions in the laboratory. The fertilized eggs develop into embryo and continue incubated for 5-6 days until reach the blastocyst stage of embryo. Then the embryo is will be transferred into uterus or frozen.

ICSI is a technique to assist fertilization for men with high level of defect sperms, low ability for fertilization. ICSI is generally performed under a microscope using a single good quality sperm directly injection into an egg and then let the fertilization happens.  

The difference between IVF and ICSI
The difference between IVF and ICSI is in the method of fertilization. IVF fertilization methods are closely natural fertilization which a sperm get into an egg and fertilized itself. The embryologist will release prepared sperm around the egg, only the strongest sperm can get into an egg for fertilization.

For ICSI (Intracytoplasmic Sperm Injection, selected healthy sperm only 1 sperm and injected into 1 egg by specialized equipment under a microscope for achieve fertilization. The ICSI method can increase the fertilization rate and reduce abnormal fertilization problems.

IVF treatment with embryo chromosome screening
Abnormality of embryo may cause the implantation not to occur, incomplete implantation or pregnancy with an abnormal fetus. This problems is usually found in mothers older than 35 years. Nowadays we bring technology is used to screen abnormalities of embryo chromosome (Preimplantation Genetic Test for Aneuploidy: PGT-A) and select only the embryo with normal chromosomes transferred back into the uterus. This will increase the pregnancy rate, reduce the risk of miscarriage and reduce the chance of fetal abnormalities.